Inhibitory Effect of Dexamethasone Palmitate-Low Density Lipoprotein Complex on Low Density Lipoprotein-Induced Macrophage Foam Cell Formation.
نویسندگان
چکیده
منابع مشابه
Effect of Lycopene on Formation of Low Density Lipoprotein-Copper Complex in Copper Catalyzed Peroxidation of Low Density Lipoprotein, as in vitro Experiment
Background: A great deal of evidence has indicated that oxidatively modified LDL plays a critical role in the initiation and progression of atherosclerosis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper...
متن کاملEvidence of Macrophage Foam Cell Formation by Very Low-Density Lipoprotein Receptor Interferon-g Inhibition of Very Low-Density Lipoprotein Receptor Expression and Foam Cell Formation in Macrophages
Background—Expression of the VLDL receptor, primarily in macrophages, has been confirmed in human and rabbit atherosclerotic lesions. The high binding affinity of the VLDL receptor for remnant particles implicates the VLDL receptor pathway in the foam cell formation mechanism in macrophages. This study investigates the effect of interferon (IFN)-g on VLDL receptor expression in phorbol-12-myris...
متن کاملOxidation of low-density lipoprotein and macrophage derived foam cells.
Copper-oxidized LDL has many of the characteristics of the modified LDL generated in the artery wall during the initial stages of atherosclerosis. It is not, however, a chemically defined species but shows significant variations in both its chemical composition and behaviour in biological systems depending upon the extent to which the peroxidation reaction has occurred (Fig. 1). Taking care to ...
متن کاملeffect of lycopene on formation of low density lipoprotein-copper complex in copper catalyzed peroxidation of low density lipoprotein, as in vitro experiment
background: a great deal of evidence has indicated that oxidatively modified ldl plays a critical role in the initiation and progression of atherosclerosis. antioxidants that can prevent ldl oxidation may act as antiatherogens. copper is a candidate for oxidizing ldl in atherosclerotic lesions. the binding of copper ions to ldl is usually thought to be a prerequisite for ldl oxidation by copper...
متن کاملPlasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.
OBJECTIVE The plasmin/plasminogen system is involved in atherosclerosis. However, the mechanisms by which it stimulates disease are not fully defined. A key event in atherogenesis is the deposition of low-density lipoprotein (LDL) on arterial walls where it is modified, aggregated, and retained. Macrophages are recruited to clear the lipoproteins, and they become foam cells. The goal of this st...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2000
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.23.466